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Pandemic Has Put Many Clinical Trials on Hold

Fewer clinical trials are being completed during the pandemic, which experts say could affect medical research for decades to come.

Previously, it was reported that more than 80% of clinical trials were suspended between March 1 and April 26, 2020, with the pandemic cited as the main reason.

In this study, researchers at Penn State College of Medicine examined more than 117,000 tria...

NIH Starts Trial Looking at Rare Allergic Reactions to COVID Vaccines

A new clinical trial will investigate whether people who are highly allergic or have what's known as a mast cell disorder are at higher risk for a sudden allergic reaction to the Moderna or Pfizer COVID-19 vaccines.

"The public understandably has been concerned about reports of rare, severe allergic reactions to the Moderna and Pfizer-BioNTech COVID-19 vaccines," said Dr. Anthony Fauci, d...

No Proof COVID Vaccines Can Trigger Guillain-Barré Syndrome

Two people in the Johnson & Johnson COVID-19 vaccine trial developed Guillain-Barré syndrome, but it's highly doubtful the vaccine is to blame, according to a just-published case study.

Although both people were in the same trial, one was given the vaccine and the other was given a placebo of saline solution.

"That strengthens the possibility that the case in our report may have be...

Can Vaccinations Stop COVID Transmission? College Study Aims to Find Out

It's the question everyone wants answered because reopening the world depends on it: Can coronavirus vaccines stop transmission of the virus?

Now, 21 universities across the United States are teaming up to find out.

The project, called Prevent COVID U, was started by the COVID-19 Prevention Network housed at the Fred Hutchinson Cancer Research Center in Seattle.

The study inc...

Can a Drug Help Prevent Diabetic Vision Loss?

The overall eye health of people with diabetes benefits from preventive drug injections directly into the eyeball, but it's too soon to tell whether such treatment will better preserve their vision long-term, new clinical trial results show.

Regular injections of aflibercept (Eylea) caused a more than threefold reduction in blood vessel leakage inside the retina, and a more than twofold r...

Will High-Protein Diets Help the Middle-Aged Build Muscle?

Middle-aged adults looking to boost their muscle mass do not need to bulk up on protein, a new study suggests.

Researchers found that 10 weeks of strength training plus a moderate amount of protein were enough to build muscle in previously sedentary middle-aged people. And extra protein brought no added gains.

The findings run counter to a common belief among exercisers, said resear...

Coming Soon: Once-a-Week Insulin Injections?

Daily insulin jabs can be the bane of existence for people who live with type 2 diabetes, but an investigational once-weekly insulin shot may be a game changer for these folks.

While the research is still in its early stages, the new drug called basal insulin Fc (BIF) is given once a week and appears to be just as effective at controlling blood sugar (glucose) as insulin degludec, the gol...

Common Type 2 Diabetes Meds Won't Raise Breast Cancer Risk: Study

Widely used diabetes and obesity drugs don't increase the risk of breast cancer, a new study indicates.

The drugs -- called glucagon like peptide-1 receptor agonists or GLP-1 RAs for short -- are effective in treating type 2 diabetes and obesity and in reducing heart disease. But some previous studies have suggested a possible link between them and breast cancer.

GLP-1RAs include al...

Disappointment and Hope From Two HIV Prevention Trials

An antibody infusion being tested for preventing HIV does not seem to thwart most infections -- but its success against certain strains of the virus suggests researchers are on the right track.

That's the takeaway from a clinical trial that put the antibody, called VRC01, to the test in 2,700 people at high risk of contracting HIV.

Researchers found that infusions of the antibody ev...

Could a New Drug Help Ease Alzheimer's?

About 7 out of 10 Alzheimer's patients wound up free of the brain plaques that are a hallmark of the disease after treatment with a potentially breakthrough experimental drug, clinical trial results show.

The drug, donanemab, also significantly slowed the patients' brain decline, according to findings published March 13 in the New England Journal of Medicine.

Donanemab diss...

Medical Bill Worries Tied to Worse Outcomes for Cancer Patients: Study

Financial worries can hamper the success of cancer treatment and raise patients' risk of death, according to a new study that offers the first evidence of such a link.

"The association we found was very strong, and very concerning," said senior study author Dr. Anurag Singh, director of radiation research at Roswell Park Comprehensive Cancer Center in Buffalo, N.Y. "If you are worried abo...

Could a Drug Prevent Type 1 Diabetes in Those at Risk?

Just two weeks of treatment with an experimental drug can delay the onset of type 1 diabetes by several years, researchers report.

The drug, called teplizumab, is already under review by the U.S. Food and Drug Administration based on earlier evidence of its effectiveness.

If it gets the green light, it would become the first drug approved for delaying type 1 diabetes in high-risk pe...

'Rerouting' Brain Blood Flow: Old Technique Could Be New Advance Against Strokes

Doctors are testing a decades-old surgical technique as a new way to treat certain stroke patients. And the preliminary results look promising, they say.

At issue are strokes caused by intracranial atherosclerosis, where blood vessels within the brain become hardened and narrowed.

Strokes occur when the blood supply to the brain is disrupted, depriving tissue of oxygen and nutrients...

NIH Halts Trial of Convalescent Plasma for Mild COVID-19

A clinical trial evaluating the use of convalescent plasma in patients with mild to moderate COVID-19 symptoms has been halted because the treatment didn't benefit them, according to the U.S. National Institutes of Health.

Convalescent plasma (also called "survivor's plasma") is derived from the blood of patients who have already recovered from COVID-19. It's thought that infusions of the...

Does an Arthritis Drug Help Patients Battling Severe COVID? It Depends on the Study

Two new studies suggest that the jury is still out on whether the arthritis drug tocilizumab helps those with severe COVID-19.

Both reports were published recently in the New England Journal of Medicine. The first, from scientists at the University of California, San Diego, found tocilizumab didn't improve outcomes or reduce the risk of death in patients with severe COVID-19 pneu...

Stem Cell Injections Show Early Promise Against Spinal Cord Injuries

Spinal cord injuries can be devastating to the more than 17,000 Americans who suffer them each year. But many patients may have new reason for hope: Early research suggests infusions of stem cells could help them regain lost sensation and movement.

These improvements may occur within days or weeks of receiving the stem cell therapy, and can last at least six months, according to the small...

Rheumatoid Arthritis Meds May Help Fight Severe COVID-19

Rheumatoid arthritis drugs may save lives of patients hospitalized with severe cases of COVID-19, according to a groundbreaking clinical trial.

The findings, first announced in January, have now been peer-reviewed and published in a major medical journal.

"We are delighted that our full results are now published after peer review. This confirms the robustness of our findings, that t...

New Hope for Better Treatments Against Macular Degeneration

A number of new treatments for age-related macular degeneration (AMD), a progressive eye disease, are under development. AMD is a leading cause of vision loss in older people.

About 11 million Americans have AMD, which affects part of the eye that allows you to see fine detail. There are two types: wet and dry. Wet AMD is treated with eye injections every month or two, and dry AMD with an...

New Rabies Prevention Treatment Also Works in Kids: Study

Getting bitten by a dog or wild animal is frightening, especially for kids, but a new study may help relieve some of the worry about catching rabies.

The rabies prevention treatment KEDRAB is safe and effective for patients 17 and younger, a groundbreaking pediatric clinical trial has shown.

The trial included 30 kids with suspected or confirmed rabies exposure who were treated with...

Injected Drug Delivers Up to 20% Weight Loss in Trial

A new weight-loss drug is almost twice as effective as current medications, clinical trial results show, and experts say it could revolutionize the treatment of obesity.

Overweight and obese people lost an average 15% of their body weight using a weekly injectable 2.4 milligram dose of semaglutide (Ozempic), a new report reveals.

What's more, one-third of all participants lost 20% o...

Interferon Shot Might Keep COVID-19 Patients Out of the Hospital

An experimental antiviral drug known as peginterferon lambda can speed up COVID-19 patients' ability to shed the virus and recover, scientists report.

"One of the important things about this treatment that's different from the other things that have been studied for COVID-19 is that this is working on the person, not on the virus. So it doesn't depend at all on the strain or the sequence ...

CBD Won't Help Addicts Kick the Coke Habit: Study

Cannabidiol (CBD) products are seemingly everywhere these days, but they won't help cure a cocaine addiction, a Canadian study finds.

CBD, a chemical in the cannabis plant, has long been touted as a treatment for cocaine addiction. But researchers at the University of Montreal Hospital Research Center found that it doesn't lessen addicts' craving for cocaine or reduce their risk of relaps...

Strict Low-Carb Diets Could Push Type 2 Diabetes Into Remission, But Effect Fades

Tough limits on carbohydrates in your meals can help get type 2 diabetes under control -- but the benefits typically wane over time, a new research review shows.

The analysis of 23 small trials found that low-carb diets worked better than other eating plans in helping people lose weight and send their type 2 diabetes into remission. That was true, at least, in the first six months.

...

New Hope Against Diseases Marked by Progressive Scarring of Lung Tissue

An inhaled medication might make every day physical activity a bit easier for patients with serious scarring of the lungs, a new clinical trial finds.

The study, published online Jan. 13 in the New England Journal of Medicine, involved patients with high blood pressure in the lungs caused by interstitial lung disease (ILD).

ILD is a broad term for progressive scarring of th...

Johnson & Johnson's One-Dose COVID Vaccine Promising in Early Trial

WEDNESDAY, Jan. 13, 2021 -- A single-shot COVID-19 vaccine from Johnson & Johnson has shown very strong results in early clinical trials, potentially providing a significant boost to U.S. vaccination efforts.

The vaccine produced an immune response of all 805 clinical trial participants within two months of inoculation, according to results published Jan. 13 in the New England Journal...

Vaccine Rollout Could Have Americans Back to Normalcy by Summer, Expert Says

A return to normal life in America might happen sooner than many expect, one of the nation's leading vaccine experts told HD Live! this week.

As the new coronavirus rages across the country, President-elect Joe Biden has set a goal of one million doses of vaccine delivered every day once he takes office. If that ambitious target is realized, everyday conditions in the United States might ...

Could Umbilical Cord Stem Cells Be a Lifesaver Against Severe COVID-19?

Stem cells derived from a baby's umbilical cord can help save the lives of the sickest COVID-19 patients, results from a small new clinical trial suggest.

Severely ill COVID patients who received two intravenous doses of stem cells three days apart were much more likely to survive and recover quickly, researchers found.

"The results are quite spectacular," said senior researcher Dr....

Study Finds No Benefit From Supplemental Oxygen During Labor

For decades, women have commonly been given oxygen during childbirth, but a new research review finds little evidence it benefits newborns.

The American College of Obstetricians and Gynecologists recommends that women be given supplemental oxygen when fetal heart monitoring shows an abnormal heart rate. That's based on the possibility that oxygen deprivation is causing the problem.

...

Trials Find Full-Dose Blood Thinners May Harm, Not Help, COVID Patients in ICU

Because COVID-19 is known to raise the odds for dangerous blood clots, blood thinners have quickly become part of routine care for many hospitalized patients.

But three clinical trials testing full doses of these drugs in COVID-19 patients have now paused recruitment of critically ill patients because the medications could end up doing more harm than good.

According to experts at th...

Can Mindfulness Help Ease Migraine?

A mind-body practice that combines meditation and yoga might help people better manage migraine pain, a new clinical trial finds.

The trial, which tested the effects of mindfulness-based stress reduction (MBSR), found that the approach helped relieve migraine sufferers' depression and disability. It also boosted how they rated their quality of life.

MBSR is a standardized, eight-wee...

Some Older Breast Cancer Patients Can Safely Cut Down on Chemo

More women with early-stage breast cancer may be able to safely skip chemotherapy after having surgery, according to initial results from a major clinical trial.

The trial, conducted in nine countries, found that adding chemotherapy to hormone-blocking drugs brought no added benefit to a particular group of patients. Those were postmenopausal women with hormone-sensitive breast cancer tha...

AstraZeneca COVID-19 Vaccine Shows Good Results in Late Trials

AstraZeneca's COVID-19 vaccine is safe and effective, new data from late-stage trials shows.

Overall, the vaccine protected against symptomatic disease in 70% of cases, according to a team led by researchers from Oxford University in England. Among study volunteers who got a half dose and then a full dose, the rate was 90%, while the rate was 62% in those given two full doses.

Are Scientists Close to a 'Universal' Flu Vaccine?

Scientists say they may be getting closer to creating a universal flu vaccine.

In an early-stage clinical trial with 65 volunteers in the United States, an experimental vaccine triggered strong immune responses to a wide range of flu virus strains and subtypes. The immune responses lasted at least 18 months, according to the researchers at Mount Sinai Health System, in New York City.

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Your Microbiome & Vitamin D Levels May Be Linked: Study

The diversity, and therefore the health, of the microbes in your gut is linked to your levels of vitamin D, a new study suggests.

The gut microbiome is composed of bacteria, viruses and other microbes that live in our digestive tracts and are important factors in our health and risk for disease.

In this study, researchers analyzed stool and blood samples from 567 men in six U.S. cit...

How Safe Are the New COVID Vaccines?

Two COVID-19 vaccines are on the verge of approval in the United States, with pharmaceutical companies promising that millions of doses will be available to the first wave of recipients within a matter of weeks.

Creating two vaccines in less than a year is an astonishing achievement, experts say, but the next task could prove even more difficult — convincing Americans that it's safe to ...

Could the TB Vaccine Help Prevent COVID-19?

A widely used tuberculosis vaccine may help protect people against the new coronavirus or reduce the severity of COVID-19, a new study suggests.

The Bacillus Calmette-Guérin (BCG) was developed in the early 1900s and is given to more than 100 million children worldwide every year.

In the United States, BCG is approved as a vaccine for people at high risk of contracting tuberculosis...

Add Kids to COVID Vaccine Trials, Pediatricians' Group Says

Children should be included in COVID-19 vaccine trials at the earliest possible stage, a leading group of U.S. pediatricians says.

If that's not done, youngsters' lives could be at risk, according to the 67,000-member American Academy of Pediatrics (AAP).

"If we do not add children to these research trials very soon, there will be a significant delay in when children are able to ac...

A 'Stunning' Alternative Rx for Arthritic Joints?

A procedure that "stuns" pain-sensing nerves might offer relief to people with severe arthritis of the hip or shoulder, a small, preliminary study suggests.

The procedure is a form of radiofrequency ablation, where doctors use needles to send a low-grade electrical current to nerves that are transmitting pain signals from the arthritic joint to the brain. The current heats and damages the...

Chinese COVID Vaccine Appears Safe, Effective

A Chinese COVID-19 vaccine seems to be safe and effective, early trial results suggest, but one expert says the findings should be regarded with caution.

The CoronaVac vaccine is based on inactivated SARS-CoV-2 virus. It was tested in a phase 1/2 clinical trial that included more than 700 healthy volunteers, ages 18-59, who were recruited in China between April 16 and May 5.

The vac...

Drug Combo May Be Safe, Effective Therapy for Rare Leukemia

A combination of two "targeted" therapies can beat back a rare form of blood cancer -- without the toxic effects of chemotherapy, a new study has found.

In a trial of 63 patients, researchers found that the drug regimen frequently wiped out all signs of the cancer -- a subtype of the blood cancer acute lymphoblastic leukemia (ALL). And at 18 months, 95% of patients were still aliv...

Newer Rheumatoid Arthritis Drug May Help Ease Tough-to-Treat Cases

A recently approved rheumatoid arthritis medication appears to be an effective second-line therapy when biologic treatments start to fail, a new clinical trial reports.

Arthritis sufferers treated with upadacitinib had a significantly greater reduction in their symptoms and disease activity than people treated with a standard disease-modifying antirheumatic drug (DMARD), said co-resea...

New Drug Could Extend Life for People With ALS

An experimental drug combination lengthens survival for patients with amyotrophic lateral sclerosis (ALS), new research shows.

A previous clinical trial found that the two-drug combo -- called AMX0035 -- slowed progression of the neurodegenerative disease over six months.

The new clinical trial of 137 patients with the disease, also known as Lou Gehrig's disease, found that ...

Minimally Invasive Procedure May Free Type 2 Diabetics From Insulin

A small study suggests that a new procedure that treats part of the intestine just beyond the stomach may allow people with type 2 diabetes to safely stop taking insulin.

The procedure -- which resurfaces the duodenum -- was combined with a popular kind of diabetes medication called GLP-1 receptor agonists (such as Victoza, Trulicity, Ozempic) and counseling on lifestyle factors, such a...

Once-a-Week Insulin for Type 2 Diabetes Shows Promise in Early Trial

Type 2 diabetes can be tough to control without medication. But for some people, the thought of daily shots makes them delay or avoid starting insulin therapy.

Now, new research offers some hope for those insulin avoiders -- a once-a-week insulin injection may someday replace daily shots.

A phase 2 trial compared the new weekly insulin, called icodec, to the commonly used i...

Immunotherapy Drug Boosts Survival With Bladder Cancer

An immunotherapy drug significantly improved survival in patients with the most common type of bladder cancer, according to a new study.

About 550,000 new cases of bladder cancer are diagnosed worldwide each year, making it the 10th most common type of cancer, the study authors noted.

Chemotherapy is the initial standard of care for advanced bladder cancer. After chemotherap...

Could the MMR Vaccine Help Prevent COVID-19? New Trial May Tell

A new clinical trial will try to determine whether the measles, mumps and rubella (MMR) vaccine can protect health care workers from being infected with COVID-19.

Hundreds of millions of people have received the MMR vaccine since it was developed nearly 50 years ago. It's usually given to children before age 6. Growing evidence suggests that the vaccine may also prevent COVID-19.

...

Experimental Drug Shows Promise Against ALS

An experimental treatment may help slow the progression of the deadly brain disease amyotrophic lateral sclerosis (ALS), a new study finds.

Researchers called the results a promising step in the fight against a devastating and invariably fatal disease. And two advocacy groups are calling for swift action to make the drug available to patients.

ALS is also known as Lou Gehrig...

Multiple Studies Confirm Steroids Can Fight Severe COVID-19

A slew of "gold standard" clinical trials offer new hope for patients battling severe COVID-19: cheap, common drugs known as corticosteroids appear to cut the death rate by a third.

Publication of new data on treatment with corticosteroids such as hydrocortisone or dexamethasone "represents an important step forward in the treatment of patients with COVID-19," said Dr. Hallie Prescott...

Artificial Pancreas Controls Diabetes in Kids 6 and Up, Clinical Trial Shows

An artificial pancreas system is safe and effective at managing blood sugar levels in kids as young as age 6 with type 1 diabetes, according to a new study.

The system uses a continuous glucose monitor (CGM) to track blood sugar levels and automatically delivers insulin when needed using an insulin pump. It replaces reliance on fingerstick or CGM with delivery of insulin by injection ...

Bee Healthy: Honey May Beat Cold Meds Against Cough

There may be no cure for the common cold, but a spoonful of honey might make it less miserable, a new research review concludes.

Parents have long used honey to soothe kids' sore throats and cough -- probably because their parents did. But the review of 14 clinical trials finds some science to back it up.

Overall, adults and kids given honey had less-severe, less-frequent co...