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Early Trial Shows New Treatment Hits Tough-to-Treat Glioblastomas Harder

Radioactive substances injected into the body could provide a better way of treating glioblastoma, the most malignant form of brain cancer, a new review says.

The cancer treatment, called targeted alpha therapy (TAT), involves injection of radioactive alpha particles attached to special molecules that seek out cancer cells in the body.

Pre-clinical experiments show that TAT increase...

Why Are Brain Tumors More Deadly for Kids in Poorer Neighborhoods?

U.S. children with inoperable brain tumors appear to die sooner and find it harder to get care if they live in poorer neighborhoods, a new study finds.

Children from higher-income areas had more than double the average survival time than kids from poorer neighborhoods -- 480 days versus 235 days, depending if a census tract had an average household income higher or lower than $50,000.

...

Your Head Aches: What Could It Mean, and What Can Be Done About It?

When there's pain, pressure and pounding in your head, you might think the worst: Is it a brain tumor?

Probably not, a Penn State physician assures. 

Headache in and of itself is not a common sign of a tumor, because the brain itself doesn't feel pain, said Dr. John Messmer, medical director at Penn State H...

Ultrasound Device Delivers Meds to Better Fight Brain Tumors

One of the biggest obstacles to treating brain cancer is getting tumor-killing drugs past the blood-brain barrier that normally protects the brain from foreign invaders.

Now, new research shows that ultrasound waves emitted from a device implanted in a cancer patient's skull could be the key to getting chemotherapy and immunotherapy drugs into the brain.

This ultrasound technology a...

Doctors May Have Tried to Treat Cancer in Ancient Egypt

A 4,000-year-old skull provides evidence that ancient Egyptians might have tried to treat cancer, a new study claims.

Microscopic observation of the skull revealed 30 or so lesions scattered across its surface that are consistent with cancer, researchers report.

T...

MRNA Vaccine Fights Deadly Brain Tumor in Small Trial

An experimental cancer vaccine can quickly reprogram a person's immune system to attack glioblastoma, the most aggressive and lethal form of brain cancer, a small, preliminary study has found.

The cancer vaccine is based on mRNA technology similar to that used in COVID vaccines, but in this case a patient's own tumor cells are used to create a personalized vaccine, researchers said.

Hormonal Meds for Birth Control, Menopause Linked to Brain Tumors

The contraceptive injection Depo-Provera and two drugs used for menopause relief could be linked to a heightened risk for brain tumors in some women, a new study warns.

Depo-Provera (medroxyprogesterone acetate) increased the risk of intracranial meningioma 5.6-fold if used for longer than a year, researchers report in the BMJ<...

New Immune-Focused Therapy Shrinks Aggressive Brain Tumors

Delivering dual-targeted, immune-focused CAR T cancer therapy via a patient's spinal fluid quickly shrank deadly brain tumors, researchers report.

CAR T therapy harnesses the power of the patient's immune system T-cells, which are reprogrammed to seek and destroy a specific protein found on cancer cells.

However, in the new trial -- focused on patients with deadly glioblastomas (...

Brain Cancer Risk Rises in Vets After Serious Head Injury

People who've suffered a moderate to severe traumatic brain injury have a greatly increased risk of brain cancer, a new study of military service members finds.

Brain cancer is relatively uncommon, occurring in fewer than 1% of people in the United States, researchers said.

But service members who had a moderate or severe brain injury were at 90% increased risk for developing malign...

Rock On: He Played Guitar While Getting His Brain Tumor Removed

Professional guitarist Christian Nolen took his stage show to an operating room last month, strumming out Deftones tunes for surgeons as they worked to remove a tumor from his brain.

Nolen's performance wasn't just for entertainment -- his guitar playing helped guide the brain surgeons during the delicate operation.

By playing the guitar during an "awake” portion of his two-hour s...

Cancer Is More Lethal For Black and Hispanic Children: Report

THURSDAY, Nov. 16, 2023 (Healthday News) -- While childhood cancer is no longer terminal for many, death rates remain higher in Black and Hispanic children, a new government report reveals.

Treatments for these rare cancers have improved drastically in recent decades, and death rates dropped for all children in 2001 -- and kept dropping for another decade.

But over the past 10 years...

Targeted Treatment Shrinks Rare Brain Tumors in Small Study

A targeted treatment has had unprecedented success in shrinking a rare brain tumor, according to clinical trial results.

These tumors are papillary craniopharyngiomas (PCPs), and the drug combo is called vemurafenib/cobimetinib.

Each of 15 patients who received one or more cycles of targeted therapy responded to treatment, with an average 91% reduction in tumor size, Mass Gene...

AI Tool 'Reads' Brain Tumors During Surgery to Help Guide Decisions

Scientists have developed an artificial intelligence (AI) tool capable of deciphering a brain tumor's genetic code in real time, during surgery -- an advance they say could speed diagnosis and personalize patients' treatment.

The researchers trained the AI tool to recognize the different genetic features of gliomas, a group of tumors that constitute the most common form of brain cancer am...

New Drug Could Be Advance Against Glioma Brain Tumors

An experimental targeted therapy can dramatically slow the progress of common slow-growing brain cancers, a new clinical trial finds.

The oral drug vorasidenib nearly tripled progression-free survival in patients with grade 2 gliomas compared to placebo, nearly 28 months versus 11 months, according to results presented Sunday at the American Society of Clinical Oncology (ASCO) annual meet...

Ultrasound Breaches Blood-Brain Barrier, Helping Drugs Fight Tumors

Brain cancers are notoriously difficult to treat because most chemotherapy drugs can't breach the blood-brain barrier, a microscopic layer of cells that protect the brain from toxins.

But researchers now say they can temporarily open that barrier and get more chemo to brain tumors, using an experimental ultrasound device.

The technology led to a four- to sixfold increase in chemo dr...

In Mouse Study, New Gel Therapy Stops Dangerous Brain Tumors

A gel applied directly into the brain could offer new hope for patients diagnosed with glioblastoma, the most common malignant brain tumor in adults.

The gel cured 100% of lab mice with glioblastoma when it was applied to the tumor cavity following surgery to remove the cancer, said senior researcher Honggang Cui,...

How Many CT Scans Are Safe for Kids?

Getting a single CT scan during childhood doesn't appear to increase a child's risk of a future brain tumor, leukemia or lymphoma, new research finds, but getting four or more scans more than doubles the chances.

CT scans use low-dose radiation, which can damage cells. Past evidence about the risks of cancer from these scans in children 18 and younger was conflicting, researchers said.

CAR-T Therapy Helps Kids Battling Deadly Nervous System Tumors

A therapy that arms the immune system to find and destroy tumor cells has shown early promise against a rare and aggressive childhood cancer.

Experts called the findings "promising." But they cautioned that much larger studies are needed to see whether and how the treatment can fit into battling the cancer, called neuroblastoma.

Neuroblastoma begins in immature nerve cells, with tum...

Be Aggressive With Initial Brain Tumor Surgery to Boost Survival: Study

Researchers studying patients with low-grade, slow-growing brain tumors have found that more aggressive surgery may extend survival.

The trick to treating low-grade gliomas is to remove as much of them as possible soon after diagnosis, researchers at University of California, San Francisco found.

"Our findings p...

Race Could Affect Outcomes in Head-and-Neck Cancers

Black patients with head-and-neck cancers have twice the death rates of white patients, and a new study suggests race itself underlies those differences.

"What is unique about our study is it strongly supports the conclusion that Black patients seem to respond to therapy differently than white patients,” said study author

  • Cara Murez HealthDay Reporter
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  • December 19, 2022
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  • Black Patients With Brain Tumors Less Likely to Get Surgery Than Whites

    Black patients with brain tumors may be less likely to have surgery recommended to them than white patients are, according to a large U.S. study.

    The research, which looked at two national databases, found that on average, Black patients were less likely to have surgery recommended for any of four types of brain tumor. That included three considered benign (non-cancerous) and one that is ...

    Implant Delivers Chemo Directly to Brain in Patients Battling Brain Tumors

    Researchers have found a way to safely deliver a steady supply of chemotherapy directly to brain tumors -- in what they hope will be an important advance for patients with currently incurable cancers.

    The treatment involves an implantable pump system that supplies a steady drip of chemo straight to the brain tumor. Researchers have tested it in five patients who had recurrent glioblastoma...

    Harnessing a Virus to Fight a Killer Brain Tumor in Kids

    A therapy that uses a virus to kill tumor cells can be safely given to children with a rare, incurable form of brain cancer, an early study has found.

    The study -- published June 30 in the New England Journal of Medicine -- involved just 12 children with the disease, called

  • Amy Norton HealthDay Reporter
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  • June 30, 2022
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  • Weight-Loss Surgery May Greatly Lower Odds for Many Cancers

    Dropping a load of pounds through weight-loss surgery can significantly decrease your risk of developing or dying from cancer, according to three new studies.

    Obese folks who underwent bariatric surgery were at least two times less likely to develop certain types of cancer and more than three times less likely to die of cancer than heavy people who didn't get the procedure, according to a...

    Wildfire Survivors Could Face Higher Cancer Risk

    Wildfires, like the one currently raging in New Mexico, are known to cause upticks in breathing issues and heart attacks in their immediate wake for folks who live nearby.

    Now, new Canadian research shows that these fires may also increase risk for lung and brain cancer o...

    Missed Cancer Screenings During Pandemic Could Raise Death Rate for Years

    The early months of the COVID-19 pandemic kept millions of Americans away from routine cancer screenings. Now a new study finds that many U.S. screening programs were still not back to normal by 2021.

    The study, of more than 700 cancer facilities nationwide, found that in January 2021 - a year after COVID's emergence in the United States - most still had not recovered their pre-pandemic s...

    Half of Americans Live With Legacy of Childhood Lead Poisoning

    If you were born before 1996, there's a good chance you were exposed to high levels of lead as a kid, and new research suggests this may have harmed your IQ and boosted your chances of lead-related health concerns down the road.

    "A significant proportion of Americans alive today had very high lead exposure as children...

    Biden Relaunches Cancer Moonshot Initiative

    President Joe Biden announced Wednesday that he is giving a new push to the cancer moonshot initiative that he first led during the Obama administration.

    In his announcement, Biden said the program would aim to boost prevention, screening and research with a target of reducing the cancer death rate by 50% over the ne...

    New Treatment Greatly Boosts Survival for Kids With Aggressive Brain Cancer

    Children with the rare cancer neuroblastoma often succumb to the disease despite aggressive treatment. But researchers have found that adding an experimental antibody to that treatment, right off the bat, may improve their outlook.

    Of 64 children treated with the antibody in a clinical trial, 74% were still alive and free of a recurrence three years later. That compares with historical ra...

    Tough Choices: Chemo That Can Save Kids With Cancer Can Also Damage Hearing

    The cancer drug cisplatin can save children's lives, but often with the side effect of hearing loss. Now a new study shows that young children are especially vulnerable, and the hearing damage may begin early in the course of treatment.

    The researchers said the findings highlight the need to screen kids' hearing during each round of cisplatin treatment, to catch problems early.

    Fewer American Adults Are Getting Malignant Brain Tumors

    Malignant brain tumor rates are declining among U.S. adults, but patients still have a low chance of survival, a new study finds.

    The researchers also found that rates of noncancerous tumors are on the rise, likely due to increased awareness and improvements in diagnosis.

    "Although the molecular understanding of how brain cancers differ from each other is advancing rapidly, we conti...

    Mixed Progress Against Cancers in Teens, Young Adults

    There's some encouraging news for U.S. teens and young adults with cancer.

    Survival rates have improved for several types of cancer, though gains have been limited for some common kinds, according to a long-term study published online July 26 in the journal Cancer.

    The researchers used a wealth of accumulated data "to piece together a larger part of the cancer survival st...

    For People With Heart Failure, Statins May Lower Cancer Risk Too

    Many people with heart failure take a cholesterol-lowering statin, and new research suggests those pills might also lower their odds for cancer.

    Researchers analyzed data from more than 87,000 people in Hong Kong who had no history of cancer and were hospitalized for heart failure between 2003 and 2015.

    They were followed until they were diagnosed with cancer, died or until the end ...

    People Over 80 Benefit From Surgery for Benign Brain Tumors

    Surgery for the most common type of benign brain tumor should be considered for patients 80 and older, Finnish researchers say.

    Meningiomas originate in the meninges surrounding the brain, and the primary treatment is surgery. But the risks of operating increase with age, so surgery for meningioma patients who are 80 and older is rare in most countries, according to University of Helsinki...

    When Heart Attack Strikes, Cancer Patients Often Miss Out on Lifesaving Treatment

    Too few cancer patients who have a heart attack are receiving emergency angioplasties that could save their lives, a new study finds.

    "This is an important study, which underscores the broader issue in cardio-oncology of cancer patients too often being passed over for potentially beneficial procedures," said Dr. Robert Copeland-Halperin, a cardiologist unconnected to the new research.

    ...

    Toxin in Undercooked Meat Shows Links to Rare Brain Tumors

    A foodborne pathogen may be linked to a type of rare brain cancer in adults, a new study suggests.

    Researchers found that people who have glioma are more likely to have antibodies to toxoplasma gondii than a similar group that was cancer-free. That indicates they were previously infected with the parasite, which is most commonly acquired from undercooked meat.

    The investig...

    New Clues to How Cancers Originate in the Brain

    Researchers say a new study may offer hope for future patients with glioblastoma, an aggressive brain cancer. It's the brain tumor that killed Senators John McCain and Ted Kennedy.

    Investigators from the University of Toronto discovered that the healing process after a brain injury could spur tumor growth if new cells meant to replace those lost in the injury were derailed by mutations.

    Tumors Have Their Own Bacterial Colonies That Could Guide Cancer Care

    The human body is teeming with bacteria, and a new study finds the same is true of many cancers -- raising questions about what role microbes might play in the diseases.

    Researchers have already known that tumors in certain areas of the body -- like the gut -- harbor bacteria of their own. But the new research reveals that a range of cancers, including those of the breast, lungs, bone...

    Fewer Kids in Cancer Trials, Which Might Not Be a Bad Thing

    There's been a sharp decline in the number of U.S. children taking part in cancer clinical trials over the past few decades, but researchers say that might be good news.

    Why? Having more effective treatments available now may be one reason for that decrease, they explained.

    The researchers, from the University of Colorado Cancer Center, analyzed national data and found that ...

    Could AI Help Doctors Map Out Treatments for Brain Cancers?

    Artificial intelligence may reduce the need for glioma brain cancer patients to have biopsies to determine the best treatment for their tumors, researchers report.

    Currently, it's common to remove glioma samples from patients and analyze them to select appropriate therapy.

    But scientists have been testing imaging techniques that might be used instead of biopsies to assess gl...

    Brain Cancer Research Could Help Dogs -- and the Humans Who Love Them

    Few heartbreaks are as devastating as when a beloved family dog falls ill with cancer.

    But a new research paper could spur development of more and better treatments for a canine companion who has a brain tumor -- because it's possible that those same therapies will help human kids, too. Dogs' brain cancers are genetically akin to those found in children, a new study in the journal ...

    More Aggressive Surgery Can Extend Survival From Brain Cancer: Study

    Adults with glioblastoma -- the most common and deadly type of brain tumor -- could survive more than twice as long if surgeons removed surrounding tissue as well as the tumor, a new study finds.

    That involves cutting out "non-contrast-enhancing tumor" -- which doesn't light up on an MRI when a contrast agent is injected -- as well as contrast-enhancing tumor.

    "Traditionally...

    Fewer Childhood Cancer Survivors Getting Hit by Heart Troubles

    Since the 1970s, serious heart disease among childhood cancer survivors had declined remarkably, a new study finds.

    The decline suggests that efforts to make cancer treatments, including radiation, less toxic are paying off, researchers say.

    For the study, researchers led by Dr. Daniel Mulrooney, from St. Jude Children's Research Hospital in Memphis, Tenn., collected data ...

    Surgery May Add Years for Patients With Deadly Brain Cancer: Study

    Surgical removal of the entire tumor may extend the lives of patients with a rare and deadly type of brain cancer called brainstem high-grade gliomas, a new study suggests.

    Researchers analyzed data from 103 patients in the United States who had either a biopsy (15%) or had surgery to remove part or all of the tumor (85%) between 1973 and 2015. Of those who had surgery, about...

    Jimmy Carter Recovering From Broken Pelvis After Fall

    Former U.S. President Jimmy Carter is recovering in a Georgia hospital after he broke his pelvis in a fall at his home on Monday night.

    "He has been admitted to Phoebe Sumter Medical Center for observation and treatment of a minor pelvic fracture," said a statement issued early Tuesday by The Carter Center. "He is in good spirits and is looking forward to recovering at home."

    <...

    Brain Tumor Patient Used Medical Pot, Landed in ER

    Folks who use medical marijuana need to beware of super-concentrated products now on the market, a new case report warns.

    A 52-year-old brain cancer patient taking a pot concentrate to boost his appetite landed in the ER after taking a dose 35 times stronger than a recreational user might take, said report author Dr. Jeanmarie Perrone, director of toxicology and addiction medicine with ...

    New Treatments Could Be Powerful Weapons Against Brain Tumors

    New therapies are showing real promise in fighting the type of brain cancer that claimed the lives of Sens. John McCain and Ted Kennedy, a pair of new clinical trials shows.

    One experimental treatment injects powerful genes directly into a brain tumor, and then uses pills to turn the genes on and off. That way, the genes can attack the cancer without going berserk and damaging other p...

    MS Linked to Higher Cancer Risk

    MONDAY, July 1, 2019 (HealthDay News) -- Multiple sclerosis is a tough disease to manage and live with, but a new, long-running Norwegian study suggests it might also raise cancer risk.

    Overall, the higher risk was small -- just 12%. However, the risk of certain cancers -- such as central nervous system (brain, spinal cord and optic nerve) cancers and urinary cancers were around ...

    Childhood Brain Tumor Survivors Face More Struggles

    Adult survivors of childhood brain tumors often face intellectual and financial struggles, a new study finds.

    Advances in treatment have prolonged the lives of many childhood brain tumor patients, but survivors may have to contend with a number of effects from the disease and its treatment, the researchers noted.

    To learn more, they compared 181 American and Canadian surviv...

    Better Treatments Needed to Boost Brain Cancer Survival: Study

    Glioblastoma brain cancer remains one of deadliest tumors, and new research shows five-year survival rates remain low for patients with the disease.

    While there have been improvements in short- and medium-term survival rates for patients with the most common type of brain tumor in adults, only 6% of patients live for five years after diagnosis, according to the Mayo Clinic researc...