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Drug Combo Marks Advance Against Bladder Cancer

A cancer drug duo more than doubled the survival of people battling the most common form of advanced bladder cancer, trial results show.

Patients who took a combo of meds called EV+P -- enfortumab vedotin and pembrolizumab (Keytruda) -- had an average 31.5 months survival, compared to just over 16 months for those on standard chemotherapy, researchers reported March 7 in the

  • Ernie Mundell HealthDay Reporter
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  • March 11, 2024
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  • Full Page
  • Treatment Strategy Helps People With Advanced Bladder Cancer Retain the Organ

    “Listen, I'm not a Pollyanna,” New Yorker David Cabelis makes clear. “I'm a cab driver.”

    “But I was diagnosed with this cancer,” the 72-year old said. “Bladder cancer, that's what I had, and then I had this treatment, and it was the most amazing experience. And thank God, now I'm clean, I'm cancer-free. So, if you're asking me about this treatment, I'll tell you one thing: I...

    Could Loss of the Y Chromosome Help Speed Cancers in Men?

    It's common knowledge that loss is a part of male aging — loss of hair, loss of muscle tone, loss of vision or hearing.

    But men growing older also start losing the very thing that makes them biological males, their Y chromosome, and that can leave them more vulnerable to cancer, a new study says.

    The loss of the Y chromosome can help cancer cells evade detection by the body's immu...

    Patients With Bladder Cancer May Avoid Removal of Extra Lymph Nodes, Study Finds

    For years, doctors have thought that a more extensive surgery that removes a wider swath of lymph nodes was the best option for certain patients with bladder cancer. Now, a new clinical trial is upending that belief.

    Researchers found that the strategy — known as extended lymphadenectomy — was no better than standard surgery at prolonging patients' lives or the amount of time they li...

    FDA Approves Gene Therapy for Tough-to-Treat Bladder Cancer

    Patients with a high-risk bladder cancer now have a new option to treat it.

    The U.S. Food and Drug Administration on Friday approved a gene therapy called Adstiladrin, which is designed to work for patients who have what's called high-risk non-muscle-invasive bladder cancer (NMIBC) that hasn't responded to the standard treatment, Bacillus Calmette-Guérin (BCG), but hasn't spread. BCG is ...

    U.S. Cancer Death Rates Continue to Decline

    The latest statistics from the U.S. National Cancer Institute (NCI) show a continuing decline in the number of Americans who die from cancer, although there's been little change in the number of new cancer cases.

    "From 2015 to 2019, overall cancer death rates decreased by 2.1% per year in men and women combined," according to a statement issued by the NCI on Thursday.

    The biggest d...

    Football Great Terry Bradshaw Describes Battle Against Two Kinds of Cancer

    Football Hall of Famer Terry Bradshaw revealed Sunday that he has been treated for two different types of cancer in the past year.

    Bradshaw talked about his health while co-hosting Fox NFL Sunday.

    “Last week on ...

    Immunotherapy Drug Can Lower Recurrence When Bladder Cancer Spreads

    Immunotherapy with nivolumab (Opdivo) after surgery for metastatic bladder cancer significantly reduces the odds for the tumor's return, a new clinical trial finds.

    Among 700 patients with urothelial cancer of the bladder or other parts of urinary tract that had spread to musc...

    Missed Cancer Screenings During Pandemic Could Raise Death Rate for Years

    The early months of the COVID-19 pandemic kept millions of Americans away from routine cancer screenings. Now a new study finds that many U.S. screening programs were still not back to normal by 2021.

    The study, of more than 700 cancer facilities nationwide, found that in January 2021 - a year after COVID's emergence in the United States - most still had not recovered their pre-pandemic s...

    More Evidence That Pandemic Delayed Cancer Diagnoses

    New research offers fresh proof that the COVID-19 pandemic delayed cancer diagnoses in the United States, increasing patients' risk for poor outcomes.

    For the study, researchers analyzed data from more than 9 million patients at over 1,200 Veterans Affairs (VA) medical facilities.

    Procedures to diagnose cancer were used less often and there were fewer new cancer diagnoses in 2020 t...

    Cancer Care Costs U.S. $156 Billion Per Year; Drugs a Major Factor

    Private insurers paid out about $156.2 billion in 2018 for U.S. patients with the 15 most common cancers.

    Medication was the largest expense and drugs for breast, lung, lymphoma and colon cancers accounted for the largest chunk of those costs, according to a Penn State College of Medicine study.

    "The public often hears that the U.S. spends an inordinate amount of money on health car...

    For People With Heart Failure, Statins May Lower Cancer Risk Too

    Many people with heart failure take a cholesterol-lowering statin, and new research suggests those pills might also lower their odds for cancer.

    Researchers analyzed data from more than 87,000 people in Hong Kong who had no history of cancer and were hospitalized for heart failure between 2003 and 2015.

    They were followed until they were diagnosed with cancer, died or until the end ...

    Women, Take These Key Steps to Good Urological Health

    Women who try to hold their pee during the day might want to rethink that strategy.

    It's time to "get up and go," according to the Urology Care Foundation, which is encouraging women to be proactive about their urological health.

    That, of course, means get up and go to the bathroom if you need to. But the foundation also suggests a number of activities a woman can get up and go...

    Can You Keep Your Bladder After Bladder Cancer Strikes?

    After being diagnosed with bladder cancer, some patients face an almost impossible decision -- have their bladder removed or take a risk knowing that the cancer may be more likely to spread if the bladder is left intact.

    But what if there was another way?

    For David Cabelis, 68, the decision was more straightforward than most, as he had a unique opportunity to take part in a clinical...

    Obesity Raises Odds for Many Common Cancers

    Being obese or overweight can increase the odds of developing several types of cancers, new research from the United Kingdom reveals.

    But shedding the excess pounds can lower the risk, researchers say.

    Reducing obesity cuts the risk for endometrial cancer by 44% and uterine cancer by 39%, and could also prevent 18% of kidney cancers and 17% of stomach and liver cancers, according t...

    Therapeutic Cancer Vaccine Shows Promise Against Multiple Tumor Types

    Marc Baum went through all the usual steps to treat his bladder cancer -- a couple of surgeries, radiation therapy and chemotherapy, all in a three-month period.

    But doctors hope that an extra step -- an experimental vaccine -- will be what keeps Baum's cancer from coming back.

    A vaccine that uses genetics to teach a person's immune system how to precisely target the cancer has prov...

    Urinary Incontinence Surgery Won't Raise a Woman's Cancer Risk

    Women face no increased risk of pelvic cancer -- tumors of the bladder, cervix and ovaries -- if they have surgery to treat stress urinary incontinence (SUI), a new study finds.

    Concerns about possible complications and safety issues related to use of surgical mesh -- particularly for a condition called pelvic organ prolapse, and also for SUI -- have made some patients reluctant to have m...

    Adding in Stem Cell Therapy Helps Beat a Common Childhood Leukemia

    Combining stem cell transplants with cutting-edge immunotherapy prevents leukemia relapses in young people and improves their chances of survival, new research suggests.

    Acute lymphoblastic leukemia is the most common childhood cancer.

    This study included 50 patients (ages: 4 to 30) with acute lymphoblastic leukemia who received CAR T-cell therapy. The treatment genetically modifies...

    When Heart Attack Strikes, Cancer Patients Often Miss Out on Lifesaving Treatment

    Too few cancer patients who have a heart attack are receiving emergency angioplasties that could save their lives, a new study finds.

    "This is an important study, which underscores the broader issue in cardio-oncology of cancer patients too often being passed over for potentially beneficial procedures," said Dr. Robert Copeland-Halperin, a cardiologist unconnected to the new research.

    ...

    Cancer Survivors at Higher Odds for Second Cancer: Study

    Cancer survivors are at greater risk of developing another cancer and dying from it, a new study finds.

    These new cancers can result from a genetic predisposition, from treatments such as radiation and chemotherapy used to fight the first cancer, as well as from unhealthy lifestyles such as smoking and obesity, according to researchers from the American Cancer Society.

    Some of these...

    Even Winter Carries Skin Cancer Risks for College Students

    Researchers from two universities in Utah have a warning for students planning to hit the slopes or play in the snow without sunscreen: You could greatly increase your risk of skin cancer.

    A survey of students by Brigham Young University College of Nursing in Provo found that only 9% use sunscreen. They also found students' use of tanning beds surges in winter, especially among men.

    Quit Smoking, Your Bladder Will Thank You

    If you smoke, you significantly increase your odds of developing bladder cancer, experts warn.

    "Everyone knows smoking causes lung cancer, but they don't always know about bladder cancer," said Dr. Srinivas Vourganti, a urologist at Rush University Medical Center in Chicago who specializes in treating bladder and other urinary tract cancers.

    Smoking causes more than half of all case...

    MS Has Mixed Impact on Patients' Cancer Risk: Study

    How does having multiple sclerosis (MS) affect a person's odds for cancer? The answer may depend on the type of cancer, new research shows.

    The study found that MS patients do have much greater odds of developing bladder cancer compared to people without the illness. But there was good news, too: Their risk of breast and colon cancer is no higher than for people who don't have MS, accordi...

    Smoking Reduces Survival Odds After Bladder Cancer Surgery

    Patients who have surgery for bladder cancer fare worse if they smoke, new research shows.

    "This study is important because while it is known that tobacco smoking is the leading cause of bladder cancer, this is the first study to suggest that smoking puts bladder cancer patients at risk after diagnosis," said study co-author Dr. Giovanni Cacciamani. He's an assistant professor of res...

    Immunotherapy Drug Boosts Survival With Bladder Cancer

    An immunotherapy drug significantly improved survival in patients with the most common type of bladder cancer, according to a new study.

    About 550,000 new cases of bladder cancer are diagnosed worldwide each year, making it the 10th most common type of cancer, the study authors noted.

    Chemotherapy is the initial standard of care for advanced bladder cancer. After chemotherap...

    Drug Combo Offers Hope Against Advanced Bladder Cancer

    A combination of chemotherapy and immunotherapy may slow the progress of metastatic bladder cancer and extend survival, a clinical trial suggests.

    Current treatment for advanced bladder cancer is chemotherapy, but adding the immunotherapy drug atezolizumab (Tecentriq) appears to help more patients fight this disease. It strikes 81,000 Americans a year and kills 18,000.

    "Th...

    Welcome to the 'Smart Toilet' That Can Spot Disease

    Few think of the toilet as a font of valuable information, outside what you might read while you're sitting on the throne.

    But a "smart toilet" is being developed that will help track your health by analyzing your excretions, researchers say.

    The toilet would be fitted with technology that can detect a range of disease markers in stool and urine, said Seung-min Park, a senio...

    Blood Test Could Spot 50 Different Cancers

    A simple blood test for dozens of cancers is in the works.

    Researchers say their test can detect more than 50 kinds of cancer at early stages and pinpoint their location in the body.

    "If these findings are validated, it will be feasible to consider how this test might be incorporated into a broader cancer screening strategy," said lead researcher Dr. Michael Seiden, preside...

    Mouse Study Suggests Vaping Might Raise Cancer Risk

    The nicotine in e-cigarette vapor appears to cause cancer in mice, a new lab study suggests.

    The proportion of mice who developed lung cancer after a year's exposure to nicotine-laced e-cigarette vapor was about four times that of mice who breathed only filtered air, the researchers found.

    Mice exposed to the nicotine vapor were even more likely to develop pre-cancerous grow...

    Childhood TB Shot May Offer Long-Term Protection from Lung Cancer

    A tuberculosis vaccine commonly used in other parts of the world might reduce a person's risk of developing lung cancer if given early in childhood, a six-decade-long study reports.

    The Bacille Calmette-Guerin (BCG) vaccine is the only vaccine approved for preventing tuberculosis (TB) -- a potentially fatal infectious disease that typically attacks the lungs. Because TB risk is low i...

    Your Drinking Water May Harbor Cancer-Causing Nitrate: Study

    Millions of tons of nitrate from industrial farming find their way into America's drinking water each year, causing thousands of cases of cancer and other health problems, an environmental advocacy group says.

    In a new report, researchers from the Environmental Working Group (EWG) quantify the risk. They say nitrate is responsible for nearly 12,600 cases of cancer a year.

    "...

    Quitting Smoking Helps Shield Women From Bladder Cancer: Study

    If you're an older woman who smokes, quitting may bring a health benefit you haven't considered: A new study suggests it lowers your risk of bladder cancer.

    The largest decline in risk was in the first 10 years after quitting, with a modest but steady decline in following years.

    Bladder cancer is fairly rare -- about 4.6% of new cancer cases in 2019 -- but is the most c...

    Researchers Seek Firefighters for Data on Cancer Risk

    Learning more about firefighters' increased risk for certain cancers is the aim of a voluntary registry being created by the U.S. National Institute for Occupational Safety and Health (NIOSH).

    It's seeking more than 1.1 million firefighters to participate in the National Firefighter Registry.

    "Firefighters put their lives on the line to ensure our safety in emergencies, but ...