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Started Early, Drug Combo Eases Fatigue of Rheumatoid Arthritis: Study
  • Robert Preidt
  • Posted June 26, 2020

Started Early, Drug Combo Eases Fatigue of Rheumatoid Arthritis: Study

Early and intensive treatment with methotrexate and prednisone can ease fatigue in people with rheumatoid arthritis (RA), according to a new study.

RA causes chronically inflamed joints and that inflammation can lead to severe fatigue that isn't relieved by resting, according to the European League Against Rheumatism (EULAR).

"In addition to pain, profound fatigue reduces the quality of life for many people, even more than the swelling of the joints," EULAR's president, Iain McInnes, said in a league news release. He's a professor of rheumatology at the University of Glasgow in Scotland.

But doctors often don't pay enough attention to patients' fatigue, he added.

"Up to 90% of patients with rheumatoid arthritis report profound fatigue," said study author Diederik De Cock, a researcher at KU Leuven in Belgium.

His two-year study included 80 RA patients who began a drug regimen immediately after their diagnosis. They received either 15 mg of methotrexate a week (control group) or a combination therapy. The combo included 15 mg of methotrexate and 30 mg of cortisone (prednisone) weekly, which was eventually reduced to 5 mg a week.

Methotrexate suppresses RA-related inflammation, while prednisone eases joint pain and inflammation.

Patients who had intensive treatment with the drug combo for two years were less tired than those in the control group, even though both groups had similar disease activity over time, the study found.

Differences in fatigue levels between the two groups appeared to increase over time, according to the study.

"The early course of the disease could provide an opportunity to manage fatigue," De Cock said in the release.

The study was presented as an abstract online for EULAR's E-Congress 2020, which began earlier this month. Findings presented at meetings are typically viewed as preliminary until they've been published in a peer-reviewed journal.

Based on the findings, EULAR recommends early consideration of intensive treatment even in low-risk patients with RA.

RA affects about 1% people worldwide, according to EULAR.

More information

The American Academy of Family Physicians has more on rheumatoid arthritis.

SOURCE: European League Against Rheumatism (EULAR), news release, June 17, 2020
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