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Stem Cell Therapy Boosts Quality of Life for People With Advanced Heart Failure

Patients with advanced heart failure can benefit from stem cell therapy, a large, new clinical trial has found.

Injections of stem cells programmed to heal damaged heart tissue wound up improving overall quality of life for heart failure patients, compared to those who received a placebo treatment.

“Data from one of the largest cardiovascular cell therapy trials, testing a regener...

Early Promise for Stem Cell Therapy to Curb MS

Stem cells injected into the brains of multiple sclerosis patients appear to protect them against further damage from the degenerative disease, a new study shows.

MS occurs when the body's own immune system attacks and damages the protective sheath around nerve fibers, called myelin. This disrupts messages sent around the brain and spinal cord.

MS patients who received a fetal stem ...

Clinics Hawking Bogus Stem Cell Cures for Long COVID Are Everywhere

Dozens of fly-by-night businesses are marketing unproven and potentially dangerous stem cell treatments to people experiencing long COVID, a new study warns.

Researchers have identified 38 businesses engaged in direct-to-consumer marketing of purported stem cell treatments and exosome therapies for treating COVID.

These businesses are exploiting the desperation of people with long C...

Stem Cell Therapy Could Be Breakthrough Against Type 1 Diabetes

People with type 1 diabetes lack functional islet cells in their pancreas to produce the hormone insulin and must take daily insulin via injections or a continuous pump to compensate.

But if new research pans out, some folks with type 1 diabetes may no longer need ...

Stem Cell Treatment Halts MS for Some Patients

A new study is strengthening the evidence that stem cell transplants can be highly effective for some people with multiple sclerosis -- sending the disease into remission for years, and sometimes reversing disability.

Researchers found that of 174 MS patients who underwent stem cell transplants -- with cells from their own blood -- two-thirds had no evidence of "disease activity" over 10 ...

In a First, Scientists Grow Human Kidneys Inside Pigs

For the first time ever, a solid humanized organ has been grown from scratch in an animal — a first step in a process that could potentially solve organ shortages and save countless lives.

Chinese researchers grew partially human early-stage kidneys inside embryonic pigs, using a variety of genetic engineering techniques, a new report reveals.

“This study demonstrates proof-of-p...

Blinded by Chemical Burns, Patients Regained Sight With New Stem Cell Therapy

Phillip Durst was working near an industrial dishwasher when something went awry, and the machinery spewed caustic chemicals into his eyes.

“If I had been standing a foot left or right, it wouldn't have hit me right where it did. I was just standing in the wrong place,” said Durst, 51, of Birmingham, Ala.

The chemicals caused severe burns to his eyes, blinding him.

�...

Stem Cells Might Someday Create New Tooth Enamel or 'Living Fillings'

Damaged teeth could one day be repaired with “living fillings” created from stem cells, a new study reports.

In the lab, researchers induced stem cells to form small, multicellular mini-organs that secrete the proteins that form tooth enamel, according to a report published Aug. 14 in the journal

Brain 'Organoid' Study Hints at the Origins of Autism

Research using three-dimensional replicas of the developing brain created in a lab dish is shedding new light on autism spectrum disorder.

Yale researchers found two paths to autism in the developing brain.

“It's amazing that children with the same symptoms end up with two distinct forms of altered neural networks," co-senior author

  • Cara Murez HealthDay Reporter
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  • August 11, 2023
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  • European Man May Be 6th Person to Be 'Cured' of HIV

    It's rare for someone with HIV to go into remission and be considered "cured," but a European man may be the sixth to do so.

    First diagnosed with HIV in 1990, the man had been taking antiretroviral drugs since 2005 and received a stem cell transplant two years ago to treat a rare type of blood cancer.

    Known as the “Geneva patient,” the Swiss man in his 50s is one of only six peo...

    First Synthetic Human Embryo Models Created in Lab

    Scientists say they have created the first synthetic human embryo models, not actual human embryos but models meant to simulate and better understand early human development.

    These embryo-like structures were created from single human embryonic stem cells, without eggs and sperm, by scientists in the United States and United Kingdom, CNN reported.

  • Cara Murez HealthDay Reporter
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  • June 15, 2023
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  • More Evidence Gene Therapy Might Cure Sickle Cell Disease

    A clinical trial that's attempting to discover a cure for sickle cell disease has found a new gene therapy to be safe and successful in four patients.

    Two of the patients were treated at Cleveland Clinic Children's in Ohio, and doctors there are hopeful that their positive results will be borne out in future research.

    “New treatments like this are critical for people who have sick...

    Scientists Create Monkey Embryo From Stem Cells

    Scientists have created an embryo-like structure using monkey embryonic stem cells for the first time, part of an effort to better understand early human development and organ formation.

    The researchers created the structures in a lab in China and then transferred them into the uteruses of female monkeys, according to a report published April 6 in the journal Cell Stem Cell.

    <...

    10 Years on, Stem Cell Transplant May Have Cured Patient of HIV

    A man who underwent a stem cell transplant to treat his cancer is showing "strong evidence" that the procedure also cured him of HIV -- the latest in a handful of cases doctors have reported.

    The patient, a man in his 50s, was HIV-positive when he underwent a stem cell transplant to treat leukemia. The procedure effectively gave him a new immune system -- critically, from a donor who had ...

    Stem Cell Therapy May Slow MS Better Than Meds: Study

    A new study is adding to evidence that people with multiple sclerosis can benefit from a type of stem cell transplant -- including some patients who are in a more advanced phase of the disease.

    The research is the latest look at a potential alternative treatment for some patients with MS -- using their own blood stem cells to try to reboot their faulty immune systems.

    Studies have f...

    Scientists Create Synthetic Mouse Embryo With Brain, Beating Heart

    Using only mouse stem cells, British researchers report they have created synthetic embryos that form a brain, a beating heart and other organs.

    The stem cells organized themselves until they developed beating hearts and the foundations of the brain and yolk sacs where the embryo...

    Study in Rats Offers Hope for New Parkinson's Therapy

    Experimental stem cell replacement therapy for Parkinson's disease shows promise in rats and will soon be tested in a human clinical trial, researchers say.

    "We cannot be more excited by the opportunity to help individuals who suffer from [a] genetic form of Parkinson's disease, but the lessons learned from this trial will also directly impact patients who suffer from sporadic, or non-gen...

    'Human Cell Atlas' Maps 1 Million Cell Types in 33 Organs

    An international research effort has unveiled the most extensive reference map yet of individual cells within the human body, knowledge that could revolutionize the study of health and disease.

    The massive Human Cell Atlas contains detailed maps of more than one million individual cells across 33 organs and systems, researchers announced this week.

    "You can think of it as a Google M...

    Researchers May Be Close to a Cure for Type 1 Diabetes

    Science could be well on its way to a cure for type 1 diabetes, as researchers hone transplant therapies designed to restore patients' ability to produce their own insulin, experts say.

    At least one patient - a 64-year-old Ohio man named

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  • February 25, 2022
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  • Woman Cured of HIV After Umbilical Cord Blood Transplant

    A woman with HIV who received an umbilical cord blood transplant has become the third person in the world to be cured of the virus that causes AIDS.

    The two others, both men, were cured after receiving bone marrow transplants from donors who carried a mutation that blocks HIV, The New York Times reported.

    The woman -- who is of mixed race -- was diagnosed with HIV in 2013 a...

    COVID-19 Can Cause Scarring of Kidneys: Study

    COVID-19 patients are at risk for serious long-term kidney damage, according to the results of a new investigation.

    The damage appears to come from the virus' ability to directly infect the kidneys. And in some cases, the scarring and damage may last well beyond the COVID infection itself, German, Dutch and American researchers said.

  • Alan Mozes HealthDay Reporter
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  • December 29, 2021
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  • New Clues to How Ovarian Cancer Begins -- and Might Be Prevented

    Researchers say they may be closer than ever to detecting ovarian cancer earlier and improving the odds for women with this life-threatening disease.

    In a new study, scientists used stem cells created from the blood samples of women with BRCA mutations and ovarian cancer to fashion a model of fallopian tube tissue.

    There, they found first hints of ovarian cancer in the fallopian tu...

    Could Gene Therapy Help Cure Sickle Cell Disease?

    A gene therapy that could provide a permanent cure for sickle cell disease continues to show success through a third wave of patients, researchers report.

    The therapy, LentiGlobin, restored normal blood function in 35 sickle cell patients who had the one-time procedure, according to clinical trial findings published Dec. 12 in the

  • Dennis Thompson HealthDay Reporter
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  • December 13, 2021
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  • Gene Therapy May Reverse Hurler Syndrome, a Rare and Severe Illness in Kids

    Gene therapy might soon offer a new option for children with a rare genetic disorder that damages tissues throughout the body, researchers are reporting.

    In a study of eight children with the condition, called Hurler syndrome, researchers found that the gene therapy was safe over two years. It also showed potential for beating the current standard treatment, stem cell transplantation.

    ...

    Stem Cell Therapy Boosts Outcomes for Some Heart Failure Patients

    Heart failure patients who fit a specific profile can benefit from injection of stem cells delivered directly into their heart muscle, a new study finds.

    Patients with mild or moderate heart failure who have high levels of inflammation responded well to the stem cell injections, and experienced a decline in their risk of heart attacks, strokes and heart-related death, clinical trial resul...

    Sales of Unproven, Unapproved Stem Cell Therapies Are Booming

    The sale of unproven and unapproved stem cell treatments has skyrocketed in the United States, according to a new five-year study.

    The study found a fourfold jump since 2016 in the availability of the treatments, which claim to do everything from relieving pain to slowing aging.

    People who use these treatments are needlessly spending thousands of dollars and could be putting their h...

    Bald Truth: Mouse Study May Get at Roots of Hair Loss

    New research in mice may provide clues to age-related hair loss in men and women.

    Scientists found that as hair stem cells in mice age, they lose the stickiness that keeps them secured inside the hair follicle. This allows the stem cells to drift away from the follicle.

    "The result is fewer and fewer stem cells in the hair follicle to produce hair," said study lead author Rui Yi, a ...

    Ten Years On, Gene Therapy Still Beating Most Cases of 'Bubble Boy' Immune Disease

    Nine of 10 patients with so-called "bubble boy" immune disease who received gene therapy about a decade ago are still disease-free, researchers report.

    The gene therapy was developed at the University of California, Los Angeles (UCLA), to treat the rare and deadly immune system disorder formally known as adenosine deaminase--deficient severe combined immunodeficiency (ADA-SCID).

    It'...

    Gene Therapy Uses HIV to Rescue Kids Born Without Immune System

    Cora Oakley is a rough-and-tumble 4-year-old who loves gymnastics and outdoor activities, particularly if it involves bouncing on a trampoline.

    It's hard to tell from looking at her that she was born without an immune system. Kids with this condition can acquire dangerous, life-threatening infections from day-to-day activities as simple as going to school or playing with friends.

    "I...

    Diabetes Can Lead to Amputations, But Stem Cell Treatment Offers Hope

    One of the most dangerous complications of diabetes is a foot ulcer that won't heal, but now a preliminary study finds that a type of stem cell found in body fat may be a powerful remedy for these severe foot wounds.

    The study included 63 patients with non-healing diabetic foot ulcers who were given injections of cells from their own body fat. Over the next year, the treatment healed the ...

    Adding in Stem Cell Therapy Helps Beat a Common Childhood Leukemia

    Combining stem cell transplants with cutting-edge immunotherapy prevents leukemia relapses in young people and improves their chances of survival, new research suggests.

    Acute lymphoblastic leukemia is the most common childhood cancer.

    This study included 50 patients (ages: 4 to 30) with acute lymphoblastic leukemia who received CAR T-cell therapy. The treatment genetically modifies...

    Scientists Create First Lab Model of Human 'Pre-Embryo' for Research Purposes

    Research into miscarriages, infertility and birth defects is now primed to undergo revolutionary advances, thanks to the creation in the lab of an early stage of human embryos by two separate international teams of scientists.

    Both teams were able to use human cells to create artificial blastocysts, an early stage of conception that occurs a few days after egg fertilization but prior...

    Stem Cell Injections Show Early Promise Against Spinal Cord Injuries

    Spinal cord injuries can be devastating to the more than 17,000 Americans who suffer them each year. But many patients may have new reason for hope: Early research suggests infusions of stem cells could help them regain lost sensation and movement.

    These improvements may occur within days or weeks of receiving the stem cell therapy, and can last at least six months, according to the small...

    Could Stem Cell Therapy Be a Breakthrough Against MS?

    Stem cell transplants may have long-lasting benefits for some people with aggressive cases of multiple sclerosis, a new study suggests.

    Italian researchers found that among 210 multiple sclerosis (MS) patients who received a stem cell transplant -- with cells from their own blood -- two-thirds saw no worsening in their disability 10 years out.

    That included 71% of patients with rela...

    Promising Steps Toward Retinal Cell Transplants to Fight Blindness

    A promising step toward using retinal cell transplants to treat blindness is reported in a new study.

    Adult retinal stem cells from deceased human donors survived when they were transplanted into the eyes of non-human primates, according to the researchers.

    The cells were taken from the retinal pigment epithelium (RPE). It is a layer of cells that supports and nourishes the retina, ...

    New Clues to How Cancers Originate in the Brain

    Researchers say a new study may offer hope for future patients with glioblastoma, an aggressive brain cancer. It's the brain tumor that killed Senators John McCain and Ted Kennedy.

    Investigators from the University of Toronto discovered that the healing process after a brain injury could spur tumor growth if new cells meant to replace those lost in the injury were derailed by mutations.

    Could Umbilical Cord Stem Cells Be a Lifesaver Against Severe COVID-19?

    Stem cells derived from a baby's umbilical cord can help save the lives of the sickest COVID-19 patients, results from a small new clinical trial suggest.

    Severely ill COVID patients who received two intravenous doses of stem cells three days apart were much more likely to survive and recover quickly, researchers found.

    "The results are quite spectacular," said senior researcher Dr....

    Could Gene Therapy Cure Sickle Cell Disease? Two New Studies Raise Hopes

    A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients' bone marrow cells, researchers report.

    Both therapies work by switching on a gene that promotes production of fetal hemoglobin, said Dr. Lewis Hsu, chief medical officer of the Sickle Cell Disease Association of America.

    Sickle cell dis...

    Parkinson's Patient Improving After First-Ever Stem Cell Therapy

    In a first, scientists have treated a Parkinson's disease patient with his own skin cells -- repurposing them to become key brain cells that the disease kills off.

    Two years after receiving the experimental treatment, the patient has had no adverse effects, his doctors report. His symptoms, meanwhile, have either stabilized or gotten somewhat better.

    "The improvement has be...

    Transplanted Skin Stem Cells Help Blind Mice See Light

    Transplants of skin cells that were turned into light-sensing eye cells enabled blind mice to detect light, a new study says.

    In previous research with lab animals, scientists have programmed stem cells created from blood or skin cells to become photoreceptors and transplanted them into the back of the eye.

    Researchers said this study shows that it's possible to skip the ste...

    Are Immune-Compromised Kids at Greater Risk From COVID-19?

    One of the few bright spots in the COVID-19 pandemic has been the perception that children are mostly spared from its worst effects. But what about kids already at risk of contracting serious infections due to a compromised immune system? Do they have the same protection?

    "One group we always worry about when it comes to viral illnesses is immunocompromised children," said Dr. Reggie...

    Young-Onset Parkinson's May Start in the Womb, New Research Suggests

    People who develop Parkinson's disease at a younger age (before age 50) may have malfunctioning brain cells at birth, according to a study that also identified a drug that may help these patients.

    At least 500,000 people in the United States are diagnosed with Parkinson's each year. Most are 60 or older at diagnosis, but about 10% are between 21 and 50.

    Parkinson's is ...

    New Clues Show How Stress May Turn Your Hair Gray

    The next time you tell your rebellious teenagers that their antics are giving you gray hair, know that the latest animal research seems to confirm your claim.

    Scientists report they have pinpointed how stress causes gray hair in mice, and they said that their findings improve knowledge of how stress can affect the human body.

    "Everyone has an anecdote to share about how stre...

    Heart Cells Change During Spaceflight

    It sounds scary, but the changes are only temporary: Researchers report that heart cells grown in space showed altered gene expression.

    But just 10 days after being returned to Earth, the heart cells returned to normal.

    Once stem cells grew into heart cells aboard the International Space Station, their exposure to microgravity changed the expression of thousands of genes.

    Study Uncovers Racial Gaps in Treatment of Multiple Myeloma

    There are significant racial disparities in treatment of U.S. patients with multiple myeloma, a new study shows.

    Researchers reviewed nationwide data on 3,504 white, 858 black and 468 Hispanic patients treated from 2007 to 2013.

    The average time between multiple myeloma diagnosis and start of treatment was 2.7 months for whites; 4.6 months for Hispanics; and 5.2 months for b...

    New Moms Can Save a Life By Donating Cord Blood

    Pregnant women should keep in mind that donating their umbilical cord blood could save lives, a clinical cell therapy expert says.

    Cord blood is the blood collected from the umbilical cord and placenta after the birth of a healthy baby, said Fabio Triolo. He is director of the Cellular Therapy Core laboratories at University of Texas Health Science Center at Houston.

    Cord bl...

    More 'Buyer Beware' Warnings for Unregulated Stem Cell Clinics

    Folks who get treatment from a stem cell clinic could be spending their money on what amounts to snake oil, a new study warns.

    Doctors administering stem cells might have no expertise in the condition they're trying to treat, and the cells themselves might be derived from questionable or discredited sources -- if the treatment contains any stem cells at all.

    "The stem cell treat...

    Can Stem Cells Be the Cure for Baldness?

    Could wigs, weaves or transplants someday become a thing of the past? Scientists report they were able to grow hair with stem cells in animal studies.

    So far the technique has only been tried on mice, and results may not be the same in humans. But researchers say they have been able to grow natural-looking hair through the skin using stem cells.

    This could bring new hope t...

    Buyer Beware: Many Stem Cell Clinics Lack Docs Trained in Treatments

    There's a good chance the doctor treating you at a stem cell clinic doesn't have any professional training related to your illness, researchers report.

    Anesthesiologists, dermatologists, plastic surgeons, radiologists and family doctors are among a wide range of physicians overseeing treatments at U.S. stem cell clinics for complex neurological and orthopedic diseases, the study found...

    New Facial Bone Might Someday Be Grown From the Patient's Rib

    Scientists have developed a way to grow live bone using a rib and a 3-D mold in animal studies, and they say their technique could offer a new way to treat severe head and facial injuries.

    The technique was tested in sheep. First, the researchers made a rectangular defect in the animal's jaw. Then they printed out an implantable mold and spacer made of bone cement.

    They atta...